Synaptic decision making: flipping switch-like synapses with cubic autocatalysis.
نویسندگان
چکیده
منابع مشابه
Flipping the fusion switch
dvancing cells periodically pull on their substrates to test the environment, say Grégory Giannone, Michael Sheetz (Columbia University, New York, NY), and colleagues. The actomyosin contractions both strengthen attachments to more solid substrates, and break off part of a signaling complex so that it can be carried into the cell. Once that retrograde signal reaches myosin, which is some distan...
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I t's always wise to consult others before making a big decision, so a cell seeks input from a lot of different proteins before choosing between survival and death by apoptosis. Fricker et al. describe how one particular protein— cFLIP—can nudge a cell in either direction depending on the expression levels of its three different isoforms (1). Cells contemplate suicide in response to a number of...
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During decision making between sequential stimuli, the first stimulus must be held in memory and then compared with the second. Here, we show that in systems that encode the stimuli by their firing rate, neurons can use synaptic facilitation not only to remember the first stimulus during the delay but during the presentation of the second stimulus so that they respond to a combination of the fi...
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2009
ISSN: 1662-5137
DOI: 10.3389/conf.neuro.06.2009.03.273